Advances in modelling gold nanoparticle radiosensitization using new Geant4-DNA physics models
نویسندگان
چکیده
منابع مشابه
Biological mechanisms of gold nanoparticle radiosensitization
There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties that make them ideal candidates as radiosensitizers on the basis of their strong photoelectric absorption coefficient and ease of synthesis. However, despite promising preclinical evidence...
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The major differences between the physics models in Geant4-DNA and RITRACKS Monte Carlo packages are investigated. Proton and electron ionisation interactions and electron excitation interactions in water are investigated in the current work. While these packages use similar semiempirical physics models for inelastic cross-sections, the implementation of these models is demonstrated to be signi...
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Gold nanoparticles (GNPs) have been shown to sensitize cancer cells to x-ray radiation, particularly at kV energies where photoelectric interactions dominate and the high atomic number of gold makes a large difference to x-ray absorption. Protons have a high cross-section for gold at a large range of relevant clinical energies, and so potentially could be used with GNPs for increased therapeuti...
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ژورنال
عنوان ژورنال: Physics in Medicine & Biology
سال: 2020
ISSN: 0031-9155,1361-6560
DOI: 10.1088/1361-6560/abb7c2